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340b orphan page

Download the 340B Orphan Drug Exclusion List

Updated quarterly. Free to access. 

Orphan drug exclusions are one of the most frequently mismanaged areas of 340B compliance. When your excluded drug list is out of date, you're either missing eligible claims or processing ones you shouldn't be — both carry real risk.

PharmaForce publishes an updated orphan drug exclusion list every quarter so covered entities always have a reliable, current reference for their 340B program.

What's included:

  • Full Q2 2026 orphan drug exclusion list
  • Formatted for easy import and reference
  • Reflects the latest HRSA and FDA designations

Fill out the form to download your free copy.

What is the 340B orphan drug exclusion list?

It's a list of drugs that have received FDA orphan drug designation and are therefore excluded from 340B pricing for certain covered entity types. If your entity falls under the DSH, children's hospital, or free clinic provisions, these drugs are off-limits for 340B purchasing — regardless of other eligibility factors.

 
How often is the list updated? PharmaForce publishes an updated exclusion list each quarter as orphan drug designations change. 
Does this replace other drug files? No. This is a reference resource. If you're managing compliance manually or evaluating your current TPA's accuracy, this list is a useful benchmark.
Will I get future updates? Yes. When you fill out this form, we keep your information and send you updated quarterly lists automatically.
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PharmaForce is a 340B TPA and healthcare technology company serving FQHCs, health systems, critical access hospitals, and DSH facilities. We publish this list as a free resource for the 340B community.  

Get The List